4-Oxazolecarboxylic acid, 2-phenyl-5-(trifluoroMethyl)-

4-Oxazolecarboxylic acid, 2-phenyl-5-(trifluoroMethyl)- - Names and Identifiers

Name	2-Phenyl-5-(trifluoromethyl)oxazole-4-carboxylic acid
Synonyms	4-Carboxy-2-phenyl-5-(trifluoromethyl)-1,3-oxazole 2-Phenyl-5-(trifluoromethyl)oxazole-4-carboxylic acid 4-Oxazolecarboxylic acid, 2-phenyl-5-(trifluoroMethyl)- 2-phenyl-5-(trifluoroMethyl)-oxazole-4-carboxylate acid
CAS	236736-23-5

4-Oxazolecarboxylic acid, 2-phenyl-5-(trifluoroMethyl)- - Physico-chemical Properties

Molecular Formula	C11H6F3NO3
Molar Mass	257.17
Density	1.454±0.06 g/cm3(Predicted)
Melting Point	170～172℃
Boling Point	381.3±52.0 °C(Predicted)
pKa	2.38±0.36(Predicted)
Storage Condition	2-8°C

4-Oxazolecarboxylic acid, 2-phenyl-5-(trifluoroMethyl)- - Introduction

2-Phenyl-5-(trifluoromethyl)oxazole-4-carboxylic acid is an organic compound with the chemical formula C11H6F3NO3. The following is a description of some properties, uses, preparation and safety information about the compound:

Properties: 2-Phenyl-5-(trifluoromethyl)oxazole-4-carboxylic acid is a white or off-white crystalline solid with low solubility. It has a relatively high melting point and is soluble in certain organic solvents such as acetone and methylene chloride. It is relatively stable at room temperature, but decomposes at high temperatures.

Purpose: 2-Phenyl-5-(trifluoromethyl)oxazole-4-carboxylic acid is a useful intermediate compound that can be used to synthesize other organic compounds. It has certain applications in the field of drug research and development, and can be used to synthesize some biologically active molecules, such as anti-inflammatory drugs and anti-tumor drugs.

preparation method: 2-Phenyl-5-(trifluoromethyl)oxazole-4-carboxylic acid synthesis method is more complex, usually requires a series of chemical reaction steps. One of the common synthesis methods is through the reaction: first, take 2-aminobenzaldehyde and trifluorocarbonic anhydride under alkaline conditions condensation reaction, 2-Amino-5-trifluoromethyl-4-isoxazolecarboxylic acid is obtained. Then, under acid catalysis, the target product can be obtained by esterification reaction between 2-amino-5-trifluoromethyl-4-isoxazole carboxylic acid and benzyl alcohol.

Last Update：2024-04-09 21:01:54